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This metabolite, which is around 10-fold more potent than losartan, is the result of cytochrome P450 (CYP) 2C9- and CYP3A4-mediated transformation of losartan

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Mattson et al., 2018), improves leaky gut problems and gut disorders (Rinninella et al., 2020), diminishes overweight and diabetes (Anton et al., 2018), stimulates the release of brain-derived neurotrophic factor (which stimulates the growth of nerves) (Mattson et al., 2018), and helps stave off neurodegenerative diseases like Alzheimers and Parkinsons (Mattson and Arumugam, 2018)

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Supplementary Tables S1 , S2 include a chi-square test for grouped patients, considering the data as a whole