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Long-term human safety data for Dihexa is limited
Neural Regen Res
Supplementary Information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material
It also has direct antioxidant properties, though they are generally considered less potent than those of glutathione itself
The k red value of 1.4 10 6 M 1 s 1 for PfGrx C88S (SH) 2 is about two orders of magnitude higher than the highest k ox value for PfGrx C32S/C88S (SSG) in accordance with a physiological relevance of glutaredoxins as deglutathionylating enzymes
In summary, residues C151 and C208 of reduced roGFP2 are both susceptible to enzyme-catalyzed glutathionylation with residue C208 reacting twice as fast as residue C151
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