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Dissecting detergent-insoluble proteome in Alzheimers disease by TMTc-corrected quantitative mass spectrometry

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243 adults with T2DM treated with metformin alone or in combination with a SGLT2 inhibitor were enrolled into this 52 week long substudy (study arms: tirzepatide 5 mg, n = 64

Patients with favorable genetic profiles for GLP-1 responsiveness often achieve weight loss more rapidly and may require shorter treatment durations, while those with less responsive genetic patterns may benefit from longer continuous therapy or combination approaches

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