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The mechanism involves upregulation of tissue inhibitors of metalloproteinases (TIMPs) and simultaneous downregulation of matrix metalloproteinases (MMPs), shifting the extracellular matrix balance toward net deposition rather than degradation
A human trial was done in 2023 at Western University School of Medicine published in the Journal of Antioxidants
By dissolving under the tongue, the glutathione is delivered more directly into the systemic circulation, potentially allowing for quicker onset of action and increased bioavailability compared to traditional oral dosage forms
Most protocols recommend 30-60 minutes before intended sleep
Antioxidants can be classified as either endogenous (such as glutathione, coenzyme Q10, and thioredoxin) or exogenous (such as vitamin E, vitamin C, carotenoids, and polyphenolic substances) based on their sources and characteristics
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