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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR
The results obtained by Assuno et al
It is not yet known if this happens in humans
These drugs not only help lower blood sugar but also promote weight loss and may improve cardiovascular outcomes
The p values were estimated using 2 tests for categorical variables and t tests for continuous variables
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