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In the landmark STEP trials evaluating semaglutide 2.4 mg (Wegovy), participants achieved mean weight loss of approximately 15% over 68 weeks
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hypothalamus, hippocampus, substantia nigra, ventral tegmental area (VTA), nucleus of the solitary tract (NTS)) (Cornejo et al., 2018
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KLOW peptide safety data in humans remains limited as of 2026, with most evidence derived from animal studies and early-phase observational research
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