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Research applications have expanded to encompass investigations of wound healing, tissue repair, extracellular matrix remodeling, anti-inflammatory pathways, and age-related tissue changes

This benefit is putatively driven by the systemic amelioration of metabolic risk factors like high body mass index (BMI) and hyperlipidemia, though direct preclinical evidence remains lacking

There have also been varying outcomes within classes depending on the etiology of the patients HF

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