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Which side effects and safety limits are documented

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The first one consists of the insertion of 68-bp within exon 8 ( CBS 844ins68, no rs#) that results in the duplication of a splice site at the intron7/exon 8 junction of the gene (Sperandeo et al., 1996), and two recent literature meta-analyses, both performed with 825 MDS and 1.034 control mothers, failed to find association of the CBS 844ins68 allele and maternal risk of having a DS child (Yang et al., 2013

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Recently, NASA has modified the previous risk-based radiation limits for long-term deep space flights to a new limit of 600 mSv total effective dose over an astronaut's career (205), based on the recommendation of the National Academies of Sciences, Engineering, and Medicine (206)

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