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Guidance such as the ADA/EASD Management of hyperglycaemia in type 2 diabetes consensus report (Davies et al, 2022) recommends early initiation of GLP-1 RAs or SGLT2 inhibitors along with metformin in those with established or high risk of cardiovascular disease, and it is usual practice to titrate one drug up fully before adding the second class, without waiting for further glycaemic assessment

Moreover, it is crucial to gather more information on fracture-related outcomes associated with GLP-1Ra use considering body composition alterations

Mild redness, itching, or a small bump at the injection site is normal and usually resolves within a day or two

Role of Nrf2 in the pathogenesis of atherosclerosis

Gentinetta et al

Though bariatric surgery was only available to about 2 percent of the population that was eligible for it