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Third, the K m value (Michaelis constant) of laccase for O 2 (2050 M) 16 is in the range of physiological O 2 concentrations in tissue (2964 M in the human brain for example 17 ), suggesting potential in vivo applicability

"A1 Reactive Astrocytes Activated by 2-chloroethanol Modulate M1 Microglia Polarization through Upregulating IL-1 and TNF-." Research Square

Moos S, Mohebiany AN, Waisman A, Kurschus FC

Comprehensive application of GSH chemical binding and enzymatic binding models The GSH chemical binding and enzymatic binding models are collectively termed the GSH binding model, enabling more accurate interpretation of relevant data in the research and development of covalent inhibitors

Aquaporin-4 (AQP4) is less strongly expressed in human astrocytic end-feet (Eidsvaag et al., 2009) and may respond differently in neurodegenerative conditions (Colombo et al., In vitro models of the BBB based on human cells have several advantages: (i) cellular environment may be easily and reproducibly controlled

The investigators used telomerase-negative human fetal fibroblast lines, treating with Epithalon at multiple concentrations and measuring telomerase activity by TRAP assay and telomere length by Southern blot