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GnRH agonists are very effective in shrinking fibroids, but are typically only used in women to prepare for fibroid removal surgery because of their harmful side effects
Slow titration doesn't just feel betterit actually leads to better adherence and outcomes
There was a trend of VRS worsening during the initial 3 years after radiotherapy followed by recovery
BMI and Body Weight: GLP-1 RAs were associated with notable reductions in both body mass index (BMI) and body weight across a wide range of populations
Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight management in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity), tirzepatide represents the first dual incretin receptor agonist available in clinical practice
This structural advantage allows researchers to examine sustained, long-term GLP-1 signaling dynamics rather than the short-lived responses typical of endogenous hormones
