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While the idea of taking anything resembling an amphetamine can seem scary, phentermine has a weaker effect than true amphetamines like the ones used to treat ADHD

Pancreatitis represents a rare but serious adverse reaction

High-dose ACEI with DPP-4i may diminish the effect of anti-hypertensive drugs due to increased sympathetic activation, while low-dose ACEI has no such effect

The complementary mechanisms also mean that side effects are generally not additive, though gastrointestinal symptoms may occur with both medications and require careful management during the initiation phase

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These findings provide new insights into the tolerability trade-offs of GLP-1 therapy, particularly for women