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performed a cross-trial analysis using data from clinical trials of GLP-1RAs (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER-6 [59], and AMPLITUDE-O), SGLT2is (CANVAS and CREDENCE), and finerenone (FIDELIO-DKD and FIGARO-DKD) to estimate the effects of the triple combination therapy of GLP-1RA, SGLT2i, and finerenone using the actuarial method [60]
In the OASIS-4 trial, people taking the 25 mg oral semaglutide pill lost about 16.6 percent of their body weight over 64 weeks, compared to 2.7 percent with placebo
Gut symptoms can increase during those weeks
Key Takeaway: Glutathione is the body's premier defense system
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