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362 Excess copper binds PDK1 and enhances its interaction with AKT, activating the AKT/GSK3/-catenin cascade

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[2] Choline chloride serves as an essential substrate for phosphatidylcholine and betaine formation, thereby enhancing bile-dependent lipid emulsification and acting as an osmolyte that maintains hepatocyte membrane integrity under oxidative stress

Cancer Cell 41 , 17311748.e1738 (2023)

Harmonic restraints of 200 kcal mol 1 2 were applied to the remaining atoms at each stage