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From a pharmacological perspective, tirzepatide acts primarily through GIP and GLP-1 receptor pathways to modulate insulin secretion, glucagon suppression, and appetite regulation

Semaglutide may also be available from some pharmacies as a compounded medication

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Additionally, with equivocal findings in DR and NAION, discussing personalized ocular risk of starting GLP-1RA in patients is key, and considering increased follow-up frequency after medication initiation may be warranted

doi:10.1016/j.jtcme.2018.01.001

Applying Heat or Cold: Heat can relax the muscle, so using a warm towel or heating pad on the cramp may help