It has no completed human clinical trials measuring fat loss outcomes, and it is not FDA-approved for weight management or any other therapeutic use
6 In one case involving semaglutide, lamotrigine blood levels rose from a baseline of 10.9-14.3 mcg/ml to 32.4 mcg/ml over six weeks
doi: 10.1016/S0140-6736(18)32261-X
Piperine co-administration inhibits phase II glucuronidation and sulphation via competitive enzyme inhibition, thereby augmenting systemic curcumin exposure by an estimated 2- to 20-fold in human pharmacokinetic studies, although the magnitude of enhancement varies with dose and timing (Figure 1)
JAMA , 332 (1), 8
Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A