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A circular area of pink or red skin appears at the injection site within minutes to hours after administration
7 As practitioners, the slowed gastric emptying effect raises concern for co-administered drug absorption
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Gilleran, J
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What it is / mechanism Despite 50 years of study, DSIP has no confirmed receptor, gene, or precursor protein formally identified in the literature a 2006 review in the Journal of Neurochemistry called it 'a still unresolved riddle.' Proposed mechanisms are fragmentary and not unified: links to NMDA receptor modulation, 5-HT1A-mediated thermoregulation, 1-adrenergic signaling, and possible opioid-receptor interactions have each been suggested, but none has been established as DSIP's primary mode of action
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