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The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues
Furthermore, a critical remaining gap in current translational research is the lack of stage-specific and pathway-specific efficacy data for established therapeutic agents
Looking ahead, improving tissue- or cell-specific vector targeting, building high-throughput screening platforms for FAD-sensitive variants, and using patient-derived iPSC neurons for personalized preclinical testing will be pivotal in transitioning from experimental use to clinical implementation of integrated nutrient plus gene-editing therapies
Do not repurpose research materials for any non-laboratory application
10.1034/j.1399-3003.2000.016003534.x Eur Respir J
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