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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
This is a mechanistically coherent argument for using capsules to address gut conditions specifically
Possible Side Effects Mild irritation: Redness, dryness, or itching at the application site may occur in sensitive individuals
They regulate capillary tone and diameter, thereby controlling CBF, a topic further elaborated in the subsequent section of this review
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity
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