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Biomarker Verification To verify target engagement in humans without direct hippocampal transcriptomics, peripheral proxy markers must be monitored: For Intranasal GHK-Cu (Metabolic Dampening): Monitor systemic proxies for mTOR suppression and mitochondrial load
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Yilmaz-Ersan et al., 2018)
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L., Ezra, M
Despite the use of fungal CYP51A1 inhibitors in preclinical models, their applicability to human diseases is limited due to structural differences between human and microbial CYP51A1
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