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Extension studies have shown that weight loss is generally maintained with continued therapy, though significant weight regain occurs upon discontinuationan important consideration for long-term treatment planning

The Role of GLP-1 Receptor Agonists in Restoring Metabolic Health Semaglutide binds to GLP-1 receptors throughout the body, triggering signals that slow stomach emptying, reduce hunger, and improve how your body handles blood sugar

This is usually brief and goes away if you sit down and drink water

: 10.1111/obr.13020

During titration, your body is still adjusting to the medication, and you may notice that weight loss slows or stalls temporarily

Real-world observational data, while more heterogeneous, provides a more realistic picture of outcomes across the full spectrum of users