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5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small molecule that inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that becomes overactive in metabolically aging tissue
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5-Amino-1MQ alone improved grip strength to a greater degree than rigorous exercise training alone, and combined treatment produced sustained increases in daily running distance that did not taper off in the way exercise-alone groups did, suggesting reduced post-exercise muscle recovery requirement
J., Zeng, Y
The targeted action of 5-Amino-1MQ on NNMT also suggests potential benefits in addressing age-related metabolic decline and obesity-related disorders (3)
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