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As with other incretin mimetics, retatrutide requires careful monitoring during dose escalation

Primary outcomes were myocardial infarction (MI), pulmonary embolism (PE), coronary revascularization, transient ischemic attack (TIA) or stroke, and venous thromboembolism (VTE)

This development highlights a few broader industry realities: Direct-to-consumer pharmaceutical marketing is entering a new era of scrutiny Telehealth platforms are now firmly within the regulatory spotlight Transparency around sourcing and manufacturing is becoming non-negotiable For life sciences companies, this moment reinforces something important: Innovation in delivery models whether telehealth, decentralized trials, or digital therapeutics must evolve in parallel with regulatory clarity and pharmacovigilance oversight

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This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a tightly controlled barrier, protecting the brain from the influence of external substances

Sabioni P, Le Foll B