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As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Xiong et al., 2021)

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Additionally, recent clinical evidence has demonstrated that newly diagnosed hypothyroid individuals exhibit elevated malondialdehyde (MDA) and decreased total antioxidant capacity, supporting the link between impaired antioxidant status and heightened oxidative stress (Sultana et al

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Your doctor can help you make an informed decision about whether long-term or indefinite treatment is appropriate for your situation