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280 In the early stages of AP, TNF- released from injured pancreatic acinar cells 277 exacerbates oxidative stress by converting xanthine dehydrogenase to xanthine oxidase, increases the permeability of capillary endothelial and postcapillary venule cells, and upregulates the expression of adhesion molecules such as selectin and ICAM-1, thereby facilitating leukocyte rolling, adhesion, and infiltration into pancreatic tissue
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