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But DiMarchi said his students constitute his greatest legacy

Accumulation of senescent cells is associated with reduced regenerative potential and altered tissue homeostasis

The article says animal and human data show that gradual reduction instead allows metabolic re-adaptation and lets appetite-regulation circuits normalize

The relationship between obesity and mental health is believed to be bi-directional, which means that poor mental health and psychological trauma can cause obesity, and obesity can contribute to the development of low mood and mental health conditions

Oprah said it and shes right