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Both sexes share the non negotiables: a slow, comfortable dose escalation, enough protein to hold muscle, adequate hydration to ease side effects, and the patience to stay consistent through the weeks when the scale is quiet

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Rare but serious adverse eventspancreatitis, acute kidney injury, and gallbladder eventsrequire immediate medical attention

Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and meta-analysis

10.1055/a-1792-2678 86 RubioloJ

using an Asian cohort, which may reflect differences in diabetes management, baseline cardiovascular risk, and genetic predisposition to amputation