Interestingly, lactylation of NUSAP1 at lysine 34 prevents its protein degradation and increases its expression in PDAC cells, establishing an NUSAP1-LDHA-glycolysis-lactate loop that promotes PDAC metastasis
Li RS, Gao PF, Zhang HZ, Zheng LL, Li CM, Wang J, Li YF, Liu F, Li N, Huang CZ
The original Sikiric 1999 study likewise reported "evident angiogenic property" and stimulation of granulation-tissue formation in rats (Sikiric et al., 1999)
For instance, the concomitant use of NSAIDs (non-steroidal anti-inflammatory drugs) can exacerbate kidney toxicity, which is a significant concern for those on tacrolimus therapy
doi:10.1111/j.1749-6632.2010.05479.x
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