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Both outcomes are clinically meaningful, but they illustrate why BMI at treatment initiation shapes expectations about results
Tamborlane WV, Barrientos-Perez M, Fainberg U, et al
How they did it The study group searched Google and Bing to find websites advertising semaglutide without a prescription
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Real-world dosing and outcomes 6-month persister loss about 12-13% (Hankosky DOM 2025), broad-cohort about -9.8% (Adamidis Cureus 2026), telehealth completers near -23% (Duncan Obesity Pillars 2026)
They also face an increased risk of serious and potentially life-threatening health problems
