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These drugs are particularly valuable for patients with obesity-related conditions like metabolic syndrome, prediabetes, or as recently approved, obstructive sleep apnea (OSA) the FDA approved tirzepatide in OSA because weight loss led to significant improvement in apnea-hypopnea index and symptom resolutionfda.govfda.gov
Those covered by the insurance will need to prove they have a BMI of 32 or higher, which is considered the lower levels of obesity by the Centers for Disease Control and Prevention
Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response
When epicardial adipose tissue is in excess, its potential benefits on thermoregulation and mechanical protection of the heart are countered by proinflammatory activity and with a worse haemodynamic and metabolic profile in patients with HFpEF
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