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Significant results are often only observed after (mostly unplanned) post-hoc stratification [199, 200], while pre-registered stratified analyses did not show effects [201]
Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig
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Irani also said if the medication isnt well regulated it can impact efficacy and have side effects
Data and Sources All figures on this page are taken directly from interviews or are estimates from public sources and proprietary models
