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GIP receptor activation adds something unique

I have so much more energy and focus

Kisspeptin is the notable exception, dosed at 1 to 10 mcg/kg in clinical research

In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

Lilly described it as generally mild and not typically a cause for discontinuation, but it is a new signal in this class

classified as FDA Pregnancy Category C