Senescence and the SASP: many therapeutic avenues
Advanced glycation end products (AGEs) exposure markedly impairs autophagic flux in renal TECs by activating the SMAD3/TFEB axis to suppress lysosome biogenesis and trigger lysosome depletion, leading to the accumulation of autophagosomes and SQSTM1/p62 ( Atg5 aggravates tubule injury and kidney damage, reflected as defective autophagy sensitized proximal TECs to ferroptosis (79)
So, one of the major prescription omega-3s out there is, both of them actually, Lovaza, which is a mixture of DHA and EPA, as well as Vascepa, which is a highly purified EPA, these are both prescribed by physicians to patients with hypertriglyceridemia
So, who needs B12 injections
It should not be presented as a standalone active research peptide
Glutathione IV therapy has become the popular solution for those who want to glow from within because it improves the tone of the skin, increases collagen, and fights free radicals