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Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A
Cocetta V, Ragazzi E, Montopoli M
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Established and Potential Benefits Acetyl-L-Carnitine (ALC or ALCAR) continues to be a molecule of great interest to researchers because so many important functions have been identified in preclinical research
Consistently, we found that the expression of xCT in the kidney was significantly downregulated induced by FA injection, which was closely related to the decrease in GSH levels
Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation
The combination of strong clinical data, favorable tolerability, and advancing regulatory status positions it well for expanded global availability
