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Analysis of aortic atherosclerotic tissue revealed that multiple inflammatory pathways were downregulated by semaglutide, further solidifying its potential anti-inflammatory mechanism [42]

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doi: 10.3389/fcell.2021.733908 Received 06 July 2021 Accepted 25 October 2021 Published 11 November 2021 Volume 9 - 2021 Edited by Yi Zhang, First Affiliated Hospital of Zhengzhou University, China Reviewed by Qianyi He, First Affiliated Hospital of Zhengzhou University, China Nao Yan, Wuhan University, China Updates Copyright 2021 Luo, Su, Gong, Liang, Huang, Chen, Wang and Tian

With more structural and dynamics studies on class B GPCRs, the activation process from inactive to active states via an intermediate state, i.e., allosteric communication between extracellular peptide binding and intracellular G protein coupling, will be better understood