It is a major ingredient in numerous cold and flu remedies
In this study, we have used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to characterize NAPQI binding to human glutathione S -transferases (GSTs) in vitro
Common reasons include low glutathione concentration, unstable liposomes, tablet compression destroying liposomal structure, and sub-therapeutic dosing
The compounds are studied in cell culture and animal models, and any statement that moves from "studied in a model" to "helps with" a human condition is a claim the underlying evidence does not support
See also Diabetic Med meta-analysis data cited via: Veronese N, et al
The pattern is often patchy rather than uniform, and it tends to flare most in areas where you applied the product most heavily