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While mediation analyses suggest that improved glycemic control, weight loss, and reduced blood pressure contribute to these benefits, they likely do not fully explain the observed renoprotection [36,37,38]
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GLP-1 therapies have emerged as an important innovation in addressing the global obesity challenge
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As a retrospective cohort analysis, it is inherently subject to biases such as selection bias
Moreover, because patients with T1D were excluded from studies looking at cardiovascular and renal outcomes with the use of GLP-1RA, it remains unknown whether those benefits observed in patients with T2D or obesity without T2D translate to the T1D population
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