Headaches may recur briefly after dose increases but typically resolve with continued use and supportive measures like adequate hydration
Less discussed side effects worth knowing about Beyond the common GI symptoms, both medications can produce effects that do not get enough attention in standard prescribing information
They: Increase insulin release when blood sugar rises Decrease glucagon, which helps prevent blood sugar spikes Slow gastric emptying, so food moves more gradually through the digestive tract Increase feelings of fullness and reduce appetite Signal in the brain to influence hunger, cravings, and reward Together, these effects change how your body processes food, regulates energy, and responds to hunger signals
SURPASS-4, a multicenter open-label RCT comparing treatment with tirzepatide and insulin glargine in T2D patients at increased CV risk for a median of 85 weeks, was the only study in the SURPASS program to include the change from baseline in eGFR and UACR and occurrence of eGFR decline of at least 40%, renal death, progression to end-stage kidney disease or new-onset MA among the prespecified analyses [48]
Press gently with gauze after injecting, but dont rub the area
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