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Semaglutide is a medication that mimics the effect of GLP-1, a hormone produced in your gut after you eat, and it has several effects on your body, such as: Stimulating insulin secretion and lowering blood sugar levels Slowing down gastric emptying and reducing food intake Increasing energy expenditure and fat-burning Reducing appetite and hunger Enhancing satiety and fullness Semaglutide was originally approved by the FDA as a treatment for type 2 diabetes, and in 2021, it was approved for chronic weight management in adults
The total addressable market for diabetes and weight loss in just the United States is quite large: Approximately 9% of the US population (~29M) has diabetes, including ~28M diagnosed with Type 2 Diabetes (T2D)
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Semaglutide reduces the absolute risk of major cardiovascular events by 1.5 [PMID: 38224977] Laboratory literature summary: Semaglutide reduces the absolute risk of major cardiovascular events by 1.5
In humans, members of the following classes of cytosolic GSTs are present: alpha, zeta, theta, mu, pi, sigma and omega 6
The most common include nausea, constipation, and fatigue
