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This variability raises serious concerns about dosage accuracy, effectiveness, and potential risks
The consensus-1 proposal considers only severe, recurrent flares of a small number of specific symptoms in determining a diagnosis of MCAS
395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy
Neoplasia 83 ShibataT.KokubuA.GotohM.OjimaH.OhtaT.YamamotoM.et al (2008a)
Plant Physiol 142: 775-787 Chen Z, Gallie DR (2008) Dehydroascorbate reductase affects non-photochemical quenching and photosynthetic performance
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