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Supported by the NIH (R01NS084412, R01AG089752, and R37NS083417 to B.L.)

Weeks 1 through 4: 0.25mg per week (1mg total used over 4 weeks) Weeks 5 through 8: 0.5mg per week (2mg total used over 4 weeks) Weeks 9 through 12: 1.0mg per week (4mg total used over 4 weeks) Weeks 13 through 16: 1.7mg per week (6.8mg total used over 4 weeks) Week 17 onward: 2.4mg per week (maintenance dose) During the first four weeks at 0.25mg weekly, you use only 1mg from your 10mg vial

Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid- burden via depolymerization and intestinal metabolism

Schlesinger DH, Pickart L, Thaler MM

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