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LPS administration induced an APR and consequently IL-6 responded strongly to the immune challenge with an increase to a maximum at 3 h pi followed by a decrease to the baseline until 24 h pi

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586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques