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The trial met its primary endpoint, demonstrating statistically significant and superior weight loss with CagriSema versus placebo
This modification in the protein structure ensures a reduced binding affinity of IGF-1 LR3 for IGF-binding proteins in comparison to IGF-1 [6]
Prentice et al., 1981)
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however, in advanced cancers, it drives EMT, immune evasion, stemness, and therapy resistance
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