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The underlying causes and pathological mechanisms of PD are still largely undefined, though factors such as -syn aggregation, iron overload, neuroinflammation, and lipid peroxidation are recognized as key pathogenic factors in dopaminergic neurodegeneration (7, 8)

"CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life"

J Biol Chem 270:14811484 Ursini F, Maiorino M, Brigelius-Flohe R, Aumann KD, Roveri A, Schomburg D, Flohe L (1995) Diversity of glutathione peroxidases

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Results A total of 634,265 patients were identified with MASLD/MASH