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SREBP1c ablation also promotes a compensatory upregulation of SREBP2, leading to increased hepatic cholesterol synthesis and cholesterol accumulation, linking DNL to cholesterol metabolism [46]
Tirzepatide is already FDA-approved for diabetes (sold as Mounjaro), as well as for weight loss and now sleep apnea (sold as Zepbound)
35 NakhlaM.NairA.BalaniP.UjjawalA.Arun KumarP.DasariM.et al (2024)
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