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Mol Cell Endocrinol
Consult a doctor before use if you have health conditions, are elderly, or giving to children
Cogn Behav Neurol 26:1422
Across the controlled trials Volek's recovery work (PMID 11788381), the 2021 recovery trial (PMID 34684429), the centenarian fatigue trial (PMID 18065594), and the trials pooled in the 2016 weight meta-analysis (PMID 27335245) L-carnitine was generally well tolerated, with adverse events that were mild and did not drive meaningful discontinuation
The response was dose-dependent, with higher doses producing slightly more fat loss, though the dose-response curve flattened at higher levels (Thompson et al., 2004)
For someone who wants a minimally invasive addition to their existing diet and exercise program, the risk-to-reward ratio is very low because the risks are essentially zero
