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Illustratively, there are particular distinctions from the platelet-derived growth factor (PDGF-BB) activity (Seveljevic-Jaran et al., 2006

Peptide drugs, on the other hand, can be designed to bind tightly with Mcl-1, preventing it from interacting with its natural binding partner in the cell

Other substituents: modifications can fine-tune potency and selectivity, potentially reducing off-target activity

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