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245 Before lung metastasis in breast cancer, there was a discernible alteration in the local pulmonary microenvironment, primarily characterized by a decrease in the quantity and impaired functionality of cytotoxic T lymphocytes and NK cells, potentially mediated by the primary tumor
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TLR4 activation in platelets whether by pathogen- (viremia) or damage-associated molecular patterns induces a prothrombotic and proinflammatory state (Schattner, 2019)
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