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Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]

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the SNPs were clumped for linkage disequilibrium (clumping R 2 = 0.01) (4) Calculated the F-statistics (beta 2 /SE 2 ) of SNP and excluded SNP with values less than 10 to avoid weak instrumental variable bias (5)