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2b, Table 4)
What ended in 2025 was the FDA's shortage-era enforcement discretion regarding certain compounded GLP-1 preparations, on staged dates in February and March for tirzepatide and April and May for semaglutide
The Phase II VENTURE trial successfully achieved its primary and secondary endpoints, with subjects receiving VK2735 demonstrating statistically significant reductions in body weight compared with placebo
However, some studies have shown increased levels of liver enzymes during COVID-19 [31]
PMID 34463268
For most patients, reaching goal weight does not signal the end of treatment but rather a transition from the weight loss phase to the weight maintenance phase, which typically requires continued pharmacological support for optimal outcomes as long as benefits outweigh risks
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